异喹啉骨架可由相应的β-羟基-β-苯乙胺酰基衍生物经p2o5或pocl3一类脱水剂在萘烷等惰性溶剂中回流处理来构筑。
反应机理
反应实例
参考文献
1. (a) pictet, a.; kay, f. w. ber.1909, 42, 1973?1979. (b) pictet, a.; gams, a. ber.
1909, 42, 2943?2952.
2. fritton, a. o.; frost, j.r.; zakaria, m. m.; andrew, g. j. chem. soc., chem.
commun., 1973, 889.
3. (a) ardabilchi, n.; fitton,a. o.; frost, j. r.; oppong-boachie, f. tetrahedron lett.
1977, 18, 4107?4110.(b) ardabilchi, n.; fitton, a. o.; frost, j. r.; oppong-boachie,
f. k.; hadi, a. h. a.; sharif,a. m. j. chem. soc., perkin trans. 1 1979, 539?543.
4. dyker, g.; gabler, m.;nouroozian, m.; schulz, p. tetrahedron lett. 1994, 35,
9697?9700.
5. poszávácz, l.; simig, g. j.heterocycl. chem. 2000, 37, 343?348.
6. poszávácz, l.; simig, g. tetrahedron2001, 57, 8573?8580.
7. manning, h. c.; goebel, t.;marx, j. n.; bornhop, d. j. org. lett. 2002, 4,
1075?1081.
8. holsworth, d. d. pictet–gamsisoquinoline synthesis. in name reactions in heterocyclic
chemistry; li, j. j., ed.; wiley: hoboken, nj, 2005, 457–465.(review).
9. wu, m.; wang, s. synthesis2010, 587–592.
10. caille, f.; buron, f.;toth, e.; suzenet, f. e. j. org. chem. 2011, 2120–2127,
s2120/1-s2120/25.
11. blair, a.; stevenson, l.;sutherland, a. tetrahedron lett. 2012, 53, 4084–4086.
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