名称:5-甲基-3-异噁唑羧酸乙酯
英文名称:ethyl 5-methylisoxazole-3-carboxylate
分子式:c7h9no3

分子量:155.15
cas no.:3209-72-1
结构式:image.png

规格:95%

用途:基础原料、有机中间体、医药中间体

合成工艺如下:

hydroxylammonium sulfate; ethanol; toluene;

reactants are commercially availlable.
pfizer inc., ep150984, b1, (1991) (i) ethyl 5-methylisoxazol-3-carboxylate a mixture of 0.16 mole ethyl 2,4-dioxovalerate and 0.08 mol e hydroxylamine sulfate, 50 ml ethanol and 70 ml toluene was stirred at 40°c. for four hours. the mixture was cooled to 15-20°c., 1.8 g of concentrated ammonium hydroxide added and stirring continu ed at room temperature for 60 hours. the mixture was poured into water/toluene, the aqueous layer e xtracted with toluene, the organic layers combined, washed with brine and dried (na2so4). evaporation of solvent in vacuo gave a yellow liquid which was distilled to afford 14.68 g of product, b.p. 12 0-124°c. at 30 torr which crystallized upon standing.


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