3-硫杂戊二酸二乙酯和α-二酮在碱性条件下缩合后得到的酯产物经酸性水解给出3,4-二取代噻吩-2,5-二羰基化合物。
反应机理
反应实例
参考文献
1. hinsberg, o. ber. 1910,43, 901-906.
2. miyahara, y.; inazu, t.;yoshino, t. bull. chem. soc. jpn. 1980, 53, 1187-1188.
3. gronowitz, s. in thiopheneand its derivatives, part 1, gronowitz, s., ed.; wiley-
interscience: new york, 1985,pp 34-41. (review).
4. miyahara, y.; inazu, t.;yoshino, t. j. org. chem. 1984, 49, 1177-1182.
5. christl, m.; krimm, s.;kraft, a. angew. chem. int. ed. 1990, 29, 675-677.
6. beye, n.; cava, m. p. j.org. chem. 1994, 59, 2223-2226.
7. vogel, e.; pohl, m.;herrmann, a.; wiss, t.; könig, c.; lex, j.; gross, m.;
gisselbrecht, j. p. angew.chem. int. ed. 1996, 35, 1520-1525.
8. mullins, r. j.; williams, d.r. hinsberg synthesis of thiophene derivatives. in name
reactions in heterocyclicchemistry; li, j. j., ed.; wiley: hoboken, nj, 2005, pp
199-206. (review).
9. traversone, a.; brill, w.k.-d. tetrahedron lett. 2007, 48, 3535-3538.
10. jimenez, r. p.; parvez, m.;sutherland, t. c.; viccars, j. eur. j. org. chem. 2009,
5635-5646.
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