名称：2-氨基-4-甲基噻唑-5-羧酸
英文名称：2-amino-4-methylthiazole-5-carboxylic acid
分子式：c5h6n2o2s
分子量: 158.18
cas no.：67899-00-7
结构式：
外观：类白色固体
规格：95%
用途：基础原料、有机中间体、医药中间体
合成路线如下：
sodium hydroxide; ethanol;
reactants are commercially availlable.
to a solution of ethyl 2-amino-4-methyl-1,3-thiazole-5-carboxylate 5 (3.00g, 16.1mmol) in ethanol (100ml) was added 1m sodium hydroxide solution (50.0ml) at room temperature, and the mixture was stirred for 26h. after the volatiles of the mixture were removed in vacuo, water and acetic acid were added to the residue to adjust the ph to 5.0. the resulting precipitate was collected by filtration, washed with water, and dried in vacuo to yield 6 (2.48g, 97percent) as a colorless powder. 1h nmr (200mhz, dmso-d6) delta 2.35 (s, 3h), 7.57 (s, 2h); ms (esi): m/z 159 [m h] , 157 [m?h].